Anti-Inflammatory Effect of Coxibs and their Compositions with Caffeine on the Level of Conjugated Dienes in the Formalin-Induced Edema Model

The development of novel pharmaceutical compositions, which are effective in the treatment different inflammatory diseases and have a minimum number side effects is very relevant. aim present study was biochemical confirmation anti-inflammatory activity new compositions comprising coxibs caffeine. level conjugated dienes as primary products lipid peroxidation has been evaluated plasma rats at acute inflammation caused by formalin. white male WAG line were used. content determined spectrophotometric method. It shown that combinations caffeine showed statistical significant decrease rats’ blood plasma. Caffeine enriched action effectively.